My research is aimed at understanding the molecular mechanisms underlying vascular development and diseases. Specifically, I focus on studying the crosstalk between cellular metabolism and growth factor signaling in vessel formation regulation and endothelial cell fate maintenance. To that end, I am exploiting metabolomics, transcriptome analysis, genetically engineered mouse models, and several other modern approaches. Aberrant growth factor signaling and its caused vascular dysfunction are intimately involved in many disease conditions including tumor formation and cardiac fibrosis. Therefore, my studies will not only provide fundamental insights into the roles of metabolism in vascular physiology and pathology, but also inform future work in devising new therapeutic strategies for treating human diseases.
Employment and Education
1. Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, Smet FD, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, & Simons M (2017). FGF-dependent metabolic control of vascular development. Nature, 545(7653):224-228. PMID:28467822.
2. Yu PC, Gu SY, Bu JW, & Du JL (2010). TRPC1 is essential for in vivo angiogenesis in zebrafish. Circulation Research, 106(7), 1221-1232. PMID: 20185799
3. Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, & Simons M (2012). Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation, 126(22):2589-2600. PMID: 23091063
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